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Literature summary extracted from

  • Fahrer, J.; Kaina, B.
    O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer (2013), Carcinogenesis, 34, 2435-2442.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing O6-chloroethylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine Homo sapiens
-
 DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 colon
-
 Homo sapiens
-
2.1.1.63 rectum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing O6-chloroethylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine
-
 Homo sapiens DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.63 malfunction enzyme deficiency leads to a tremendously enhanced sensitivity toward alkylation-induced colorectal carcinogenesis Homo sapiens
2.1.1.63 physiological function the suicide DNA repair protein plays role in the protection against the cytotoxic and mutagenic effects of alkylating agents causing colorectal carcinogenesis Homo sapiens